CHM 265 Announcements

---

• A lab exam study guide has been posted on the home page for this course.
• Evaluations can be filled out on Thursday.  They will be provided in the prep room along with pencils.
• Remember that Alison and any other instructor can check you out of your locker.

• Report 10 for Nucleophilic Substitution is due Thursday Dec. 6. Reports 11 and 12 will be Thursday Dec. 13 no later than 5:00 P.M.  See the Report Form web page for the individual forms.  Notebooks will be due no later then Dec. 13 5:00 P.M.  Reports and the completed notebook can be turned in early.
• Check Out Procedure
a. Clean everything including hot plates and ring stands.
b. Wipe out your drawer and hood.
c. Check for any missing equipment.
d. Replace any missing equipment.
e. Pay all bills to the Bursar.
f. Line up all equipment on a bench in the order they appear in the equipment list.
g. Have one of the instructors or Alison check you out.
h. You are done!
• Place your final liquid samples in bottles.  Seal them tightly with caps containing the plastic inserts.  Wrap the caps with parafilm. Store the Nucleophilic Substitution mixtures in the refrigerator until you they are ready to be given to me.

• Quiz 3 has been graded.  The average was 14.1/20.  The range of scores was 19.7, 17.8, 16.9, 16.7, 16.5, 16.4, 16.3, 14.1, 13.6, 11.7, 11, 9.9, and 3.  Although these scores could be better, remember that your notebook grade and some of the lab report grades will offset low scores on the quizzes and lab final. % yield and theoretical yield questions will be on the lab final.
• At this point, 240 points have been graded.  If you have > 211 points, then your grade is currently an A.  If you have > 187 points, then your grade is currently a B.
• I plan to use the same policy as last year regarding quiz points and the final exam.  In the syllabus, the quizzes are worth 100 points while the final will be also 100 points.  Depending on which leads to a higher total score, I will either multiply your current quiz total by 2 and then add in your lab final score or I will prorate your final to 150 points and then add your current quiz total out of  points.
• The lab final will be given Tuesday Dec. 11 from 1:00 - 3:00 P.M. in SB 451  It will be similar to the quizzes and will cover all the techniques used this semester and the lab notes.  Also, you may be asked to know the hazards of the compounds you have used most often this semester.  For example, methylene chloride is believed to be a carcinogen.

• Note Set 15 has been posted.

• Since the nucleophilic substitution experiment takes the whole period, and I cannot stay much after 1:30 P.M. today, the lab lecture will be posponed until next week.
• Experiment 12 has been provided as a handout.
• The report for Experiment 9 is due today.
• Experiment 6 has been graded.  The average was 16.9.  The range of scores was 19.5, 17.9, 17.9, 17.5, 17.4, 17.4, 16.9, 16.7, 16.5, 16.4, 16.4, 15.2, and 11.9.
• For the nucleophilic substitution experiment, set the rheostat to 5 initially, then reduce it to 3.5 after the reflux has started

• Note Set 14 has been posted.  There will be a lab lecture on Tuesday.
• The notebooks are finished.
• A total 180 points have been graded.  If your total > 158, that is an A.  If your total > 140, that is a B.

• Remember that Lab Quiz 3 will be given this Thursday, see 11/8/01 announcement.
• The report for Experiment 8 is due today.
• The report form for Experiment 9 has been posted.  It will be due Tuesday, Nov. 20.

11/8/01

• There will be no lab lecture today.
• Please pick up the procedure for Experiment 11 today.
• The next lab quiz will be Thursday Nov. 15.  It will cover GC, mass spectrometry, column chromatography, and calculating theoretical and % yields.
• I'm still grading your notebooks.  If your notebook has not been graded, obtain the data you need for Report 7 and turn in the notebook at the end of the period.   Don't add any new entries to your notebook until you have seen where points were lost.
• Remember Report 7 is due today.
• The report form for Experiment 8 has been posted.  It will be due Tues. Nov. 13.

• I'm still grading your notebooks.  If your notebook has not been graded, obtain the data you need for Report 7 and turn in the notebook at the end of the period.  I will have more graded on Thursday.  Don't add any new entries to your notebook until you have seen where points were lost.
• Remember Report 7 is due Thurs. Nov. 8.
• The report form for Experiment 8 has been posted.  It will be due Tues. Nov. 13.
• For the Caffeine and Nucleophilic Substitution experiments, the references for your notebook are the following:
• Pavia, D. L., Lampman, G. M., Kriz, G. S. Introduction ot Organic Laboratory Techniques, 3rd Ed. Saunders College Publishing, Philadelphia, 1988, pp. 62 - 67 (for caffeine and pp. 178-186 for nucleophilic substitution).

• Note Set 13 has been posted.

• Remember the notebooks are due today.
• Experiment 4 has been graded.  The average was 17.2.  The range of scores was 19.1, 18.5, 18, 17.5, 17.5, 17.3, 17.2, 17.1, 17, 16.8, 16.4, 16.1, and 15.4.
• Report Form 7 has been posted and will be due Nov. 8.
• All returned spectra and chromatograms should be stapled into the data sections of your notebook.
• The next lab lecture will be this Tuesday.

• There will be no lab lecture today on Experiment 10 Nucleophilic Substitution.  It will be delayed to a greater or lesser extent until; we have covered more in the lecture course.
• A separate handout will be used for Experiment 10 and has been provided today.   Please pick it up.
• We will analyze the results by GC, refractometry, and depending on the status of the instrument and time, NMR (nuclear magnetic resonance).
• The Experiment 7 report will be tentatively due Thurs. Nov. 8.  The report form will be posted soon.
• Remember that Report 6 is due today.
• The notebooks are due this Thursday.

• The procedure for Experiment 9 is provided as a handout.
• The class now has a limit of 7 late reports remaining.

• Note Set 12 has been posted.

• For Experiment 8, turn in your ferrocene and acetylferrocene immediately after weighing.  The report will be due later.
• Use the dry pack method for the column.
• Remember Report 6 will be due Tues. Oct. 30.
• The notebooks will be due Nov. 1.

• Report Form 6 has been posted, it will be due Tues. Oct. 30.
• The notebooks will be due Thurs. Nov. 1.

• Note Set 11 has been posted.

• Report 3 has been graded.  The average was 17.2/20.  The range of scores was 19.3, 19, 18.9, 18.9, 18.8, 18, 18, 17.6, 17.5, 16.3, 15.2, 14.9, 14.2, and 13.8.
• Quiz 2 has been graded.  The average was 15.4/20.  The range of scores was 19.8, 18.7, 17.5, 17.5, 17.3, 17.3, 16.5, 16.3, 15.3, 13.5, 12.2, 11.5, and 7.5.
• Note the following changes or information for the Resolution of a-Phenylethylamine Experiment.
• a-Phenylethylamine = a-methylbenzylamine
• Do not combine samples.
• Use the 1 ml volumetric flasks provided.
• Use the 1 dm. cells provided.
• The answer key for Take Home Quiz 1 has been posted in CHM 261 on REX.

• The Experiment 5 Report will be due Tuesday Oct. 16 instead of Thurs. Oct. 11.
• Two gasoline samples must be run along with the reference.  Run each gasoline sample for 7 min.  It will probably be necessary to turn the attenuator knob down 1 setting when you run the gasoline samples after the fractions.  For example, if you used an attenuation of 16 for the fractions, you will need to set the attenuator to 8 for the gasoline.
• There will be no lab lecture Thursday.  You can start working in lab immediately.
• Whenever you have time, you can start Experiment 7 The Resolution of a-Phenylethylamine.  The first part involves mixing the reagents and crystallization of the product.  The crystallization takes 2 to 3 days in your drawer.  Once the crystals form, you may collect them by vacuum filtration and let them dry.  However, don't go any further in the procedure until Tuesday's lab lecture.  The a-phenylethylamine is labeled as alpha-methylbenzylamine in the yellow cabinet.

• Note Set 10 has been posted.

• Note Set 9 has been posted.
• Report Form 5 has been posted.  It will be the longest report for the semester.

• Remember Report 4 will be due Tuesday.
• Lab Quiz 2 will be given Tuesday Oct. 9.  It will cover extraction, drying agents, IR, and distillation.
• The report for experiment 5 will be due Thursday Oct. 11.  A report form has not been posted yet.

• Note Set 8 has been posted.

• The procedure for Experiment 8 (Lab Separate) entitled Separating Ferrocene and Acetylferrocene By Adsorption Column Chromatography must purchased from the bookstore.

• The report for Experiment 4 will be due Tuesday Oct. 2.  See the Report Forms page.
• Note Set 7 has been posted.

• The notebooks have been checked for Experiments 1 and 2.  Do not rewrite the entries for these experiments, but do correct the entries for Experiments 3 and 4 where necessary.

• Note Sets 5 and 6 have been posted.

• Report 2 has been graded.  The average was 16.9.  The range of scores was 19.6, 18.9, 18.5, 17.9, 16.9, 16.9, 16.8, 16.4, 16.3, 16.2, 16.1, 15.9, 15.2,  and 15.1
• Remember Report 3 will be due 9/25/01.

• When "drying" an organic liquid, the solid drying agent is removed by either gravity filtration or decanting the liquid from the solid.  In the case of isopentyl acetate, drying agent should be removed from the crude product mixture before distillation.  In this case, decanting will minimize handling losses.
• Pick up the handout for Experiment 5 today.
• Remember to turn in your notebooks on 9/13/01.
• The report form for Experiment 3 has been posted.  It will be due 9/25/01.

• Since one report has come in late, the class now has a limit of 9 late reports left.

• Note Set 4 has been posted.
• Report 1 and Quiz 1 have been graded.  For Report 1, some m.p. and weights were incorrect.  One possibility is that the sample was still wet which would explain the higher weights but lower m.p. observed.  Also, for the m.p., sometimes the sample shrinks, or solvent from a still wet sample vaporizes and condenses (sweating) giving the appearance of melting.  Neither is considered melting.
• If you obtained a lower score on either the quiz or report, remember this is a long semester with lots of chances to recover from one of two low grades.
• The average on the quiz 8.1.  The range of scores was 10, 10, 10, 9, 9, 8.5, 8.5, 8.4, 8.2, 8, 7.2, 6.5, 5.5, and 5.2.
• The average on Report 1 was 18.2.  The range of scores 20.0, 19.0, 18.9, 18.5, 18.0, 18.0, 17.9, 17.0, 17.0, 17.0, and 16.9.

• Remember that Report 2 will be due Tuesday 9/11/01.  See Report Forms page.
• Notebooks will be due Thursday 9/13/01.  Remember this is not for a grade, but it will be checked over for improvement.

• Note Set 3 has been posted.
• You can start Experiment 4, Isopentyl Acetate on Thursday.
• Remember Report 1 is due Tuesday and the 1st quiz will be Thursday.
• Report 2 will be due Tuesday 9/11/01.  See the Report Forms page.
• Here are some tips about Experiment 3
• Not only will aspirin tail, but a faint second spot may be visible.
• The compounds in Reference 2 tend to overlap.  No points will be taken off if overlap is observed only for Reference 2.  You will have to rely on your R_f values to identify some of the spots.
• Also, be sure to use ethyl acetate + acetic acid as the eluent.  Ethyl acetate alone will not work properly.
• You can use alternative methods to make the capillary tubes, but they do need to be small capillary tubes.  If the spots are too large, separation will be poor, and points will be lost.
• In the past, part of the grade for the TLC experiment has been based on the quality of the developed TLC plates.  Points have been lost for
• spots being too large
• extra spots and marks on the TLC plates (impurities)
• curving or slanting solvent fronts
• missing spots
• spots did not travel in a path perpendicular to the bottom of the plate
• missing spots
• poor separation between spots that should separate well
• spots representing the same compound but have different R_f values

• The report for the 1st experiment will be due Tues. Sept. 4.  See the Report Form web page for a report form that lists what will be required.  All future report forms will appear on this page.  All reports are due at the end of the lab period.
• The 1st lab quiz will be Thursday September 6.  It will cover recrystallization, decolorization, filtration and melting points.  Some questions will come from the lab pertinent lab manual technique sections.
• Finish Experiments 1 and 2 and if possible start Experiment 3.
• The following sentence was added to the end of Note Set 2.
• Use 1/2 the amounts of analgesic and solvent that they suggest in the procedure.
• For Exp. 2 Aspirin, do not perform the last section on p. 52 entitled Aspirin Tablets.

• If you are waiting for a m.p. apparatus or have finished Exp. 1, then start Exp. 2 Aspirin.
• Start reading Exp. 3 Thin Layer Chromatography and tech. sections 12 and 14.
• Please place backpacks, etc. under the knee holes along the benches, it will provide more room on the bench tops.
• Clean the hoods and bench tops when you are finished.  Also notify me if your hood was dirty when you started.

• Note Set 2 has been posted.

• Note Set 1 has been posted on the Course Notes page.  You will be provided with notes in the first lab.  Afterwards, it will be necessary to download the notes from the internet.

8/13/01

• The syllabus for the course and my schedule have been posted on the CHM 265 web page.  No course notes are ready yet.  There is a lot to read for the 1st 2 experiments.  Although you should read it eventually, you won't need to know it all by the 1st experiment except for the procedure itself (Pavia, Exp. 3, pp. 57-60).