CHM 258 Organic Lab Quiz 1 Name ________________

Week of 4/17/06 (30 pt.) Form A

1. (3 pt.) There are two approaches to dealing with chemical hazards. One is to minimize exposure for a synthesis or process. The other is to avoid exposure by eliminating the hazard from the synthesis or process. What are the 2 flaws to the minimizing exposure approach?

2. (6 pt.) List 3 ways that exposure to hazards can be avoided in a chemical process (ie. Ways to make a reaction “green”).

3. (2 pt.) In the citric acid cycle, malate ( the alkene below) undergoes hydration. Water is added across the double bond in the manner shown. Is the OH adding to the re or si face of that end of the alkene? Label the priority of the groups.

4. (5pt.) Calculate the atom economy for the following reaction.

Atomic weights g/mole

H = 1.0079 C = 12.011 O = 15.9994 Na = 22.990 Br = 79.904

5. (6 pt.) List or briefly describe the three methods used in drug discovery.

6. (8 pt.) For the reaction provided, if 15.9 g. of A reacted with 14.2 g. of 1,3-butadiene, what is the theoretical yield of the reaction? If 8.6 g. of B formed, what is the % yield?